Spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells. Formed from spermidine through the addition of aminopropyl group to spermidine by spermine synthase. It is found as a polycation at physiological pH.
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Purity: ≥97%
Key Applications: DNA precipitation, Chromosome isolation, Crystallization of DNA
Product Type: Biochemicals
Biochemical Category: Organic Chemical
Boiling Point: 141-142°C at 0.5 mm Hg
Melting Point: 28-30°C (Lit.)
Presentation: Colorless Solid
pH: 11-14 (0.5% aq soln)
Solubility: Soluble in water (1% w/v), lower alcohol, chloroform; practically insoluble in ether, benzene, petroleum ether.
Storage & Handling: +4°C, desiccate, store under nitrogen