MTBSTFA and MTBSTFA+1% TBDMCS offer stable TBDMS (tert-butyldimethylsilyl) derivatization.
- Derivatizes hydroxyl, carboxyl, thiol and primary and secondary amines
- Typical yields are >96%
- Provides TBDMS ethers that are 104 times more stable to hydrolysis than TMS ethers
- Reaction byproducts are neutral and volatile
- Derivatives have a high molecular concentration at M-57
- Silylating potential increased by adding 1% TBDMS