CRP is a 224 amino acid protein that is synthesized primarily by hepatocytes, and to a lesser extent adipocytes. CRP plasma levels increase ~1,000-fold in response to acute and chronic inflammatory conditions, making it a useful gauge of inflammation in a wide range of physiological and pathological conditions. High plasma CRP concentrations (>3 µg/ml) are associated with an increased risk for atherosclerosis. Cayman’s CRP (human) ELISA is a sensitive immunometric assay which can be used to measure CRP in plasma without prior sample purification. The standard curve spans the range of 46.9-3,000 pg/ml with a limit of detection of approximately 46.9 pg/ml.