G418 DiSulfate Solution is routinely used as a selection antibiotic in cell culture gene selection applications. G418 solution is an aminoglycoside antibiotic isolated from Micromonospora rhodorangea and is closely related to the gentamicins; most notably, genatmicin B1. G418 is a generic name of Geneticin®.
G418 blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. G418 is commonly used in laboratory research to select genetically engineered cells, typically using the kanMX selectable marker.
G418 disulfate is prepared as a solution at a concentration of 50mg/mL in water for quick and easy dilution factor calculations.