Alamethacin is a mixture of alamethicin homologs. It is a membrane permeabilizing antibiotic.
Alamethicin applications includes increasing [32P] incorporation into phosphatidylinositol 4-phosphate and mermeabilization of sarcoplasmic reticulum vesicles.It causes fusion of lipid vesicles. It has also been used to study membrane interactions of antimicrobial peptides. It catalyzes the exchange of protons for monovalent cations with little difference in affinities and has the ability to transport cations through. It also causes hemolysis of erythrocytes and because it decreases the surface tension of water, it may have use as a detergent.
Purity: ≥50%
Key Applications: Increases [32P] incorporation into phosphatidylinositol 4-phosphate, Mermeabilization of sarcoplasmic reticulum vesicles, Fusion of lipid vesicles, Study membrane interactions of antimicrobial peptides, Catalyzes the exchange of protons, Hemolysis of erythrocytes, Detergent
Application Areas: Molecular biology
Product Type: Biochemicals
Melting Point: 277-278°C(Lit.)
Presentation: Tan Powder
Format: Powder
NOTES: Sequence: Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Glu-(NH2)-2-MeAla-L-Val-2- MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Glu (NH2)-L-phenylalaninol
Solubility: Soluble in DMSO and ethanol.
Storage & Handling: Store at -20°C.