IP-10, CXCL10, monkey: CXCL10 also known as IP-10 is belonging to the CXC chemokine family. It is encoded by the CXCL10 gene.
CXCL10 was originally identified in monocytes, endothelial cells, and fibroblasts as a responsor to IFN-γ.
This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3.
CXCL10 has been shown to be a chemoattractant for activated T-lymphocytes and monocytes/macrophages.
It also has other roles, such as promotion of T cell adhesion to endothelial cells, and inhibition of bone marrow colony formation and angiogenesis.
The rhesus macaque IP-10 shares 69 %, 95 %, 74 % a.a. sequence identity with human, murine, rat IP-10., UnitProt ID: Q8MIZ1