HB-EGF, rat: Platelet-derived growth factor (PDGF) presenting in serum but absent from plasma was first discovered in animal study by Lynch and co-workers in the late 1980s.
It is a disulfide-linked dimer consisting of two peptides-chain A and chain B.
PDGF has three subforms: PDGF-AA, PDGF-BB, PDGF-AB.
It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development.
The function of PDGF is mediated by two receptors (PDGFR-α and PDGFR-β)., UnitProt ID: P28576