Antigen: human PHLPP1 amino acids 1192-1205 of the α isoform, or amino acids 1704-1717 of the β isoform
Host: rabbit
Cross Reactivity: (+) human, mouse, rat PHLPP1α and PHLPP1β, (−) PHLPP2
Application(s): ICC, IHC (paraffin-embedded tissue), and WB
PHLPP1 and PHLPP2 dephosphorylate the hydrophobic motif of Akt and thus reduce Akt activity, resulting in an increase in the number of apoptotic cells.