Antigen: human EP4 receptor C-terminal amino acids 459-488
Host: rabbit
Cross Reactivity: (+) human, mouse, ovine, and rat EP4 receptors; (−) EP1, EP2, and EP3 receptors
Application(s): ICC, IHC, and WB
Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP and subsequent relaxation of smooth muscle. In addition to sequence differences, EP4 receptors are distinguished from EP2 receptors by their insensitivity to the EP2 receptor selective agonist butaprost.