Antigen: synthetic peptide corresponding to amino acids 637-650 of human DNMT1
Host: mouse, clone 60B1220.1
Isotype: IgG1κ
Cross Reactivity: (+) human, mouse, and zebrafish DNMT1
Application(s): ChIP, IHC (paraffin-embedded sections), IP, and WB
DNMT1 is constitutively expressed in proliferating cells. DNMT1 cooperates with retinablastoma tumor suppressor to repress transcription from promoters containing E2F-binding sites suggesting a link between DNA methylation and cancer cell proliferation.