Host: mouse, clone C-11
Cross Reactivity: (+) human cytokeratins 4, 5, 6, 8, 10, 13, and 18
Application(s):FC, IF, IHC (paraffin-embedded tissue), and WB
Cytokeratins make up a large family of proteins classified as intermediate filament polypeptides. They are subdivided into type I (acidic) and type II (basic/neutral) proteins. Under normal conditions, these proteins are found in epithelial cells as type I/type II pairs. These pairs provide cellular support as well as contribute to more dynamic processes. They undergo extensive post translational modifications, such as phosphorylation, and are important for cancer diagnostics.