Prostaglandin E2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4. Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Prostaglandin E2 is used in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.
Most biologically active prostaglandin. PGE2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE2-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin. The effect of PGE2 on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.
Grade: γ-Irradiated
Purity: ≥99%
Suitability: Suitable for cell culture
Key Applications: Study of prostaglandin regulated cell signaling and gene regulation
Application Areas: Cell signaling and gene regulation
Product Type: Biochemicals
Melting Point: 66°C(Lit.)
Presentation: White Solid
Format: Solid
Solubility: Sparingly soluble in water but freely soluble in organic solvents such as ethanol, methanol, acetone, acetonitrile, or DMSO. The solubility of PGE2 in these solvents is at least 10 mg/mL.
Sterility: γ-Irradiated
Storage & Handling: -20°C
Certifications: gamma-Irradiated